a Record control number WOS:000281079400005

a ISSN 1076-0296

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number WG 500

b Item number .O73 2010

a Personal name Bilgili, Hasan.

h Medium Electronic Document

a Title Oral Systemic Administration of Ankaferd Blood Stopper Has No Short-Term Toxicity in an In Vivo Rabbit Experimental Model

c Statement of responsibility, etc Hasan Bilgili, Ozge Captug, Ali Kosar, Mevlut Kurt, Murat Kekilli, Ali Shorbagi, Ozlem Kar Kurt, Oktay Ozdemir, Hakan Goker, Ibrahim Celalettin Haznedaroglu.

b Name of publisher, distributor, etc Sage publications inc,

c Date of publication, distribution, etc 2010.

a Summary, etc Background: Ankaferd blood stopper (ABS) is a standardized herbal extract obtained from 5 different plants. In Turkey, it has been approved for local topical applications in external postsurgical and postdental surgery bleedings. Ankaferd blood stopper, besides its hemostatic activity, has in vitro anti-infectious and antineoplastic actions. Objective: The aim of this study was to assess short-term hematological and biochemical safety following the oral systemic administration of ABS to rabbits. Methods: Twelve rabbits (aged 6-12 months) were included to test the safety of oral ABS. Animals were divided into 4 groups, which had ABS administered orally at doses of 1, 3, 6, and 9 mL, irrespective of their weight. The general well-being and feeding patterns of the animals were observed for a period of 7 days. Blood samples (5.5 mL) were obtained just before oral administration, on days 1 and 4. Results: During the observation period of 7 days, none of the animals showed any abnormal behavior or deviation from the normal. Acute mucosal toxicity, hematotoxicity, hepatotoxicity, nephrotoxicity, and biochemical toxicity were not observed during the short-term follow-up of the animals. Conclusions: No signs of toxicity were observed in rabbits during short-term study with oral ABS administration.

a Topical term or geographic name as entry element Peripheral Vascular Diseases

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

g Relationship information OCT 2010, Vol.16 Issue 5, p533-536

t Title Clinical and applied thrombosis-hemostasis

x International Standard Serial Number 10760296

u Uniform Resource Identifier http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1177/1076029609335912